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Recombinant Human MIP-4/CCL18

Molecule:

CCL18

Synonyms:

C-C motif chemokine18, MIP-4, CCL18, AMAC-1, DC-CK1, small-inducible cytokine A18, SCYA18

Species:

Human

Cat. No.:

CRM410C pdf (datasheet)

Quantity/Size:

1.0 mg

Price:

$2,720.00 / Special Price: $2,180.00 BUY

Description:

The C-C motif cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes, characterized by two adjacent cysteines. CCL18 (also known as Macrophage Inflammatory Protein-4/ MIP-4) displays chemotactic activity for naive T cells, CD4+ and CD8+ T cells and non-activated lymphocytes, but not for monocytes or granulocytes. It may play a role in both humoral and cell-mediated immunity, and is involved in B-cell migration in the lymph nodes. CCL18 is expressed in the lymph nodes, lungs, placenta and bone marrow.

Entrez Symbol:

CCL18

Uniprot Name:

C-C motif chemokine 18

Uniprot ID:

P55774

Source:

E. coli

Molecular Weight:

7.9 kDa (69 aa)

Physical State:

Lyophilized

Formulation:

Lyophilized from a sterile filtered aqueous solution containing 0.1% Trifluoroacetic Acid (TFA).

Purity:

≥ 95% by reducing and non-reducing SDS-PAGE

Biological Activity:

This product demonstrates chemotaxis using primary human T cells.

Endotoxin Level:

≤1 EU/µg by kinetic LAL analysis

Amino Acid Sequence:

AQVGTNKELC CLVYTSWQIP QKFIVDYSET SPQCPKPGVI LLTKRGRQIC ADPNKKWVQK YISDLKLNA

Reconstitution:

Centrifuge vial prior to opening. Add sterile distilled water to a concentration of 0.1 mg/ml. DO NOT VORTEX. Allow several minutes for complete reconstitution. Further dilutions should be made in appropriate buffered solutions.

Storage/Stability:

Store at -20°C to -80°C for up to 1 year. Upon reconstitution, the preparation is stable for up to one month at 2-8°C. For long term storage, freeze in working aliquots and store at -20 to -80°C. For maximal stability, dilute to working aliquots in a 0.1% BSA solution. Avoid repeated freeze-thaw cycles.