Synonyms:
CXCL16, C-X-C motif chemokine 16, Scavenger receptor for phosphatidylserine and oxidized low density lipoprotein, SR-PSOX, Small-inducibible cytokine B16
Description:
CXCL16 is a member of the CXC chemokine family and signals through the CXCR6
receptor. CXCL16 may play a role in attracting lymphocyte subsets during inflammation
and may facilitate certain immune responses. The chemokine domain of CXCL16
contains six cysteine residues including the four highly conserved cysteine residues
characteristic of CXC chemokines. The CXCL16 gene codes for a 273 amino acid
polypeptide, which includes a 29 amino acid cytoplasmic domain and transmembrane
sequence containing approximately 20 amino acids. The extracellular portion of CXCL16
contains a chemokines domain and an extended C-terminal "mucin-like stalk" sequence.
The extracellular domain contains 89 amino acid residues (86 a.a. residues for the
murine homolog).
Molecular Weight:
10.1 kDa (89 aa)
Formulation:
Lyophilized from sterile-filtered PBS
Purity:
> 98% by SDS-PAGE gel and HPLC analyses.
Biological Activity:
Determined by its ability to chemoattract activated lymphocytes using a concentration of 1.0 -100.0 ng/ml.
Endotoxin Level:
< 1 EU/µg
Storage/Stability:
Stable for up to 1 year stored at -20° to-80°C.
