Recombinant Human Interleukin-8/CXCL8 (77 aa)

Molecule:

IL-8/CXCL8

Synonyms:

IL-8, C-X-C motif chemokine 8, T-cell chemotactic factor

Species:

Human

Cat. No.:

CRI109B pdf (datasheet)

Quantity/Size:

25 μg

Price:

$185.00 BUY

Description:

Interleukin-8 was originally discovered and purified independently by a number of laboratories as a neutrophil chemotactic and activating factor. It was also referred to as neutrophil chemotactic factor (NCF), neutrophil activating protein (NAP), monocytederived neutrophil chemotactic factor (MDNCF), T-lymphocyte chemotactic factor (TCF), granulocyte chemotactic protein (GCP) and leukocyte adhesion inhibitor (LAI). Many cell types, including monocyte/macrophages, T cells, neutrophils, fibroblasts, endothelial cells, keratinocytes, hepatocytes, chondrocytes, and various tumor cell lines, can produce CXCL8 in response to a wide variety of pro-inflammatory stimuli such as exposure to IL-1, TNF, LPS, and viruses. CXCL8 is a member of the alpha (C-X-C) subfamily of chemokines, which also includes platelet factor 4, GRO, IP-10, etc.

Entrez Symbol:

IL8

Uniprot Name:

Interleukin-8

Uniprot ID:

P10145

Data PDF:

CRI109

Source:

E. coli

Molecular Weight:

8.9 kDa (77 aa)

Physical State:

Lyophilized

Formulation:

Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 10 mM sodium phosphate, pH 7.5

Purity:

> 95.0% by reducing and non-reducing SDS-PAGE

Biological Activity:

Biological activity is demonstrated starting at 10 ng/ml by Human neutrophil chemotaxis, and starting at 1 ng/ml for Human neutrophil degranulation.

Endotoxin Level:

< 1 EU/μg as determined by kinetic LAL analysis.

Amino Acid Sequence:

AVLPRSAKEL RCQCIKTYSK PFHPKFIKEL RVIESGPHCA NTEIIVKLSD GRELCLDPKE NWVQRVVEKF LKRAENS

Reconstitution:

Centrifuge vial prior to opening. Add sterile distilled water or aqueous buffer to a concentration of 0.1-1.0 mg/ml. Further dilutions should be made in appropriate buffered solutions.

Storage/Stability:

Store as supplied at -20°C to -80°C for up to 1 year.