Recombinant Human Endocan / ESM-1 His

Synonyms:

ESM1, ESM-1, Endocan

Species:

Human

Cat. No.:

CS421 pdf (datasheet)

Quantity/Size:

50 μg

Price:

$635.00 BUY

Description:

Endothelial cell-specific molecule1 (ESM-1), is a secreted cysteine-rich dermatan sulfate (DS) proteoglycan primarily expressed by endothelial cells within the vascular capillary network in kidney and in the alveolar walls of the lung. ESM-1 expression has also been detected in different epithelia and in adipocytes. The expression of ESM-1 is upregulated by TNFα, IL1β or lipopolysaccharide and down-regulated by IFNγ. The human ESM-1 gene encodes a 184 amino acid (aa) residues precursor protein with a 19 aa hydrophobic signal peptide and a 165 aa mature region with 18 Cysteine residues. The DS chain is covalently attached to serine 137. ESM-1 has been shown to bind CD11a/CD18 integrin (also known as lymphocyte function-associated antigen1, LFA1) on human lymphocytes, monocytes and Jurkat cells, inhibiting its binding to ICAM1 and reducing LFA1mediated leukocyte activation. Endocan binds via its DS chain to hepatocyte growth factor (HGF) to enhance HGF mitogenic activity. Genetically engineered cells overexpressing ESM-1 have been shown to induce tumor formation, suggesting that ESM- may be involved in the pathophysiology of tumor growth in vivo. Circulating ESM- can be detected in the serum from healthy subjects. In patients with lung cancer or acute and severe sepsis, elevated ESM- concentrations have been reported.

Entrez Symbol:

ESM1

Uniprot ID:

Q9NQ30

Data PDF:

CS421

Source:

Insect cells

Molecular Weight:

19.2 kDa (173 aa)

Formulation:

Lyophilized from 50 mM sodium phosphate, 300 mM NaCl, pH 8.0

Purity:

>95% by SDS-PAGE, visualized by silver stain

Biological Activity:

Not tested so far.

Amino Acid Sequence:

WSNNYAVDCP QHCDSSECKS SPRCKRTVLD DCGCCRVCAA GRGETCYRTV SGMDGMKCGP GLRCQPSNGE DPFGEEFGIC KDCPYGTFGM DCRETCNCQS GICDRGTGKC LKFPFFQYSV TKSSNRFVSL TEHDMASGDG NIVREEVVKE NAAGSPVMRK WLNPRTRHHH HHH

Storage/Stability:

Stable for 1 year at -20°C to -80°C.