Recombinant Human Fibroblast Growth Factor-10

Molecule:

FGF10

Synonyms:

Keratinocyte growth factor 2, KGF-2, FGF-10

Species:

Human

Cat. No.:

CRK001A pdf (datasheet)

Quantity/Size:

5 μg

Price:

$130.00 BUY

Description:

Fibroblast growth factor 10 belongs to the fibroblast growth factor (FGF) family which is involved in a variety of biological processes such as embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. Like most other FGF family members, FGF-10 also has a heparin-binding domain and it plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. In addition, FGF-10 may play a role in wound healing and is required for normal branching morphogenesis. Recombinant human FGF-10 shares 92% and 95% amino acid sequence identity with mouse and rat FGF-10. Defects in FGF-10 are the cause of autosomal dominant aplasia of lacrimal and salivary glands and lacrimo-auriculo-dento-digital syndrome.

Entrez Symbol:

FGF10

Uniprot Name:

Fibroblast growth factor 10

Uniprot ID:

O15520

Source:

E. coli

Molecular Weight:

Monomer, 19.3 kDa (170 aa)

Physical State:

Lyophilized

Formulation:

Sterile (0.2 micron) filtered aqueous solution containing 10 mM sodium phosphate, pH 7.5

Purity:

> 95% by reducing and non-reducing SDS-PAGE.

Biological Activity:

ED50 ≤ 200 ng/ml, determined by dose-dependent proliferation of 4MBr-5 cells.

Specific Activity:

≥ 5.0 x 10e3 units/mg

Endotoxin Level:

<1 EU/µg by kinetic LAL

Amino Acid Sequence:

MLGQDMVSPE ATNSSSSSFS SPSSAGRHVR SYNHLQGDVR WRKLFSFTKY FLKIEKNGKV SGTKKENCPY SILEITSVEIGVVAVKAINS NYYLAMNKKG KLYGSKEFNN DCKLKERIEE NGYNTYASFN WQHNGRQMYV ALNGKGAPRR GQKTRRKNTS AHFLPMVVHS

Reconstitution:

Centrifuge vial prior to opening. Add sterile distilled water or aqueous buffer to a concentration of 0.1-1.0 mg/ml. Further dilutions should be made in appropriate buffered solutions.

Storage/Stability:

Store as supplied at -20°C to -80°C.