Description:
Fibroblast Growth Factors (FGFs) are a 22 member family of proteins known to be involved in angiogenesis, wound healing and embryonic development. As a family, they bind to heparin and signal through four receptor tyrosine kinases called, FGFR1, 2, 3 and 4. Human FGF-22 is a member of the FGF-7 subfamily and is synthesized by multiple cell lines including neurons, keratinocytes and skeletal muscle myotubes. Human FGF-22 shares 86% homology with mouse FGF-22. May be involved in hair development. FGF-22 is also required for axonal circuit remodeling after spinal cord injury.
Uniprot Name:
Fibroblast growth factor 22
Molecular Weight:
17.3 kDa (149 aa)
Physical State:
Lyophilized
Formulation:
Sterile (0.2 micron) filtered aqueous solution containing 0.1% Trifluoroacetic Acid (TFA)
Purity:
≥ 95% as determined by reducing and non-reducing SDS-PAGE
Endotoxin Level:
≤ 1 EU/μg by kinetic LAL analysis
Amino Acid Sequence:
MTPSASRGPR SYPHLEGDVR WRRLFSSTHF FLRVDPGGRV QGTRWRHGQD SILEIRSVHV GVVVIKAVSS GFYVAMNRRG RLYGSRLYTV DCRFRERIEE NGHNTYASQR WRRRGQPMFL ALDRRGGPRP GGRTRRYHLS AHFLPVLVS
Storage/Stability:
Store as supplied at -20°C to -80°C for up to 1 year.
