Recombinant Human Follistatin

Synonyms:

FST, FS, Activin-binding protein.

Species:

Human

Cat. No.:

CRF024C pdf (datasheet)

Quantity/Size:

1.0 mg

Price:

$4,820.00 / Special Price: $3,720.00 BUY

Description:

Follistatin is an autocrine acting protein that is expressed by many tissues, but at noteably higher levels in the ovary and skin. Follistatin functions to negatively regulate the signaling of a wide variety of TGF-beta family members (activin, BMPs, myostatin, GDF-11 and TGF-beta 1). Mechanistically, follistatin works as an antagonist by complexing with TGF-beta family members to prevent them from interacting with their signaling receptors. Recombinant human Follistatin is a non-glycosylated protein, containing 289 amino acids.

Entrez Symbol:

FST

Uniprot ID:

P19883

Source:

E. coli

Molecular Weight:

31.7 kDa (289 aa)

Physical State:

Lyophilized

Formulation:

Sterile (0.2 micron) filtered aqueous solution containing 10 mM sodium phosphate, 50 mM sodium chloride, pH 7.5

Purity:

> 95.0% by reducing and non-reducing SDS-PAGE

Biological Activity:

≤ 200 ng/ml, determined by the dose-dependent neutralization of Human Activin A induced cytotoxicity of MPC-11 cells

Specific Activity:

≥ 5.0 x 10e3 units/mg

Endotoxin Level:

≤ 1 EU/μg, by kinetic LAL analysis

Amino Acid Sequence:

MGNCWLRQAK NGRCQVLYKT ELSKEECCST GRLSTSWTEE DVNDNTLFKW MIFNGGAPNC IPCKETCENV DCGPGKKCRM NKKNKPRCVC APDCSNITWK GPVCGLDGKT YRNECALLKA RCKEQPELEV QYQGRCKKTC RDVFCPGSST CVVDQTNNAY CVTCNRICPE PASSEQYLCG NDGVTYSSAC HLRKATCLLG RSIGLAYEGK CIKAKSCEDI QCTGGKKCLW DFKVGRGRCS LCDELCPDSK SDEPVCASDN ATYASECAMK EAACSSGVLL EVKHSGSCN

Storage/Stability:

Store as supplied at -20°C to -80°C for up to 1 year.