Synonyms:
hGDNF, astrocyte-derived trophic factor, ATF1, ATF2
Description:
Glial Cell Line-Derived Neurotrophic Factor (GDNF) is a neurotrophic factor that is closely related to other neurotrophic factors, such as Neurturin, Persephin, and Artemin, by a common structural feature called the cysteine-knot. GDNF signals through a multicomponent system of receptors that includes RET and GFRα1-4, to promote dopamine uptake, survival and differentiation of neurons.
Uniprot Name:
Glial cell line-derived neurotrophic factor
Molecular Weight:
Homodimer, 15.2/30.4 kDa (135/270 aa)
Physical State:
Lyophilized
Formulation:
Sterile filtered solution in 10 mM sodium citrate, 100 mM Sodium Chloride, pH 4.0
Purity:
>95% by reducing and non-reducing SDS-PAGE
Biological Activity:
ED50 < 3.0 µg/ml, determined by the dose-dependent proliferation of C6 cells.
Specific Activity:
4.6 x 10e2 U/mg
Endotoxin Level:
≤ 1 EU/µg by kinetic LAL
Amino Acid Sequence:
MSPDKQMAVL PRRERNRQAA AANPENSRGK GRRGQRGKNR GCVLTAIHLN VTDLGLGYET KEELIFRYCS GSCDAAETTY DKILKNLSRN RRLVSDKVGQ ACCRPIAFDD DLSFLDDNLV YHILRKHSAK RCGCI
Storage/Stability:
Store as supplied at -20 °C to -80 °C for up to one year.
