Recombinant Human GDNF

Molecule:

GDNF

Synonyms:

hGDNF, astrocyte-derived trophic factor, ATF1, ATF2

Species:

Human

Cat. No.:

CRG400B pdf (datasheet)

Quantity/Size:

10 μg

Price:

$235.00 BUY

Description:

Glial Cell Line-Derived Neurotrophic Factor (GDNF) is a neurotrophic factor that is closely related to other neurotrophic factors, such as Neurturin, Persephin, and Artemin, by a common structural feature called the cysteine-knot. GDNF signals through a multicomponent system of receptors that includes RET and GFRα1-4, to promote dopamine uptake, survival and differentiation of neurons.

Entrez Symbol:

GDNF

Uniprot Name:

Glial cell line-derived neurotrophic factor

Uniprot ID:

P39905

Data PDF:

CRG400

Source:

E. coli

Molecular Weight:

Homodimer, 15.2/30.4 kDa (135/270 aa)

Physical State:

Lyophilized

Formulation:

Sterile filtered solution in 10 mM sodium citrate, 100 mM Sodium Chloride, pH 4.0

Purity:

>95% by reducing and non-reducing SDS-PAGE

Biological Activity:

ED50 < 3.0 µg/ml, determined by the dose-dependent proliferation of C6 cells.

Specific Activity:

4.6 x 10e2 U/mg

Endotoxin Level:

≤ 1 EU/µg by kinetic LAL

Amino Acid Sequence:

MSPDKQMAVL PRRERNRQAA AANPENSRGK GRRGQRGKNR GCVLTAIHLN VTDLGLGYET KEELIFRYCS GSCDAAETTY DKILKNLSRN RRLVSDKVGQ ACCRPIAFDD DLSFLDDNLV YHILRKHSAK RCGCI

Storage/Stability:

Store as supplied at -20 °C to -80 °C for up to one year.