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Recombinant Human GM-CSF/CSF2 His

Synonyms:

Granulocyte-macrophage colony-stimulating factor, GM-CSF, Colony stimulating factor, CSF2

Species:

Human

Cat. No.:

CRG107A pdf (datasheet)

Quantity/Size:

2 μg

Price:

$215.00 BUY

Description:

GMCSF is a cytokine that controls the production, differentiation, and function of granulocytes and macrophages. The active form of the protein is found extracellularly as a homodimer. This gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5qsyndrome and acute myelogenous leukemia. Other genes in the cluster include those encoding interleukins 4, 5, and 13.

GM-CSF stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.

Uniprot Name:

Granulocyte-macrophage colony-stimulating factor

Uniprot ID:

P04141

Data PDF:

CRG107

Source:

Sf9 insect cells

Molecular Weight:

14.6 kDa (127 aa, 18-144) monomer

Formulation:

Lyophilized from sterile-filtered PBS

Purity:

Greater than 98.0% as determined by SDS-PAGE

Biological Activity:

ED50 < 0.1 ng/m, determined by the dose-dependant proliferation of human TF-1 cells (human erythroleukemic indicator cell line).

Specific Activity:

≥107 IU/mg

Reconstitution:

Reconstitute in sterile-filtered deionized water at ≥0.1 mg/ml. It is recommended to add a carrier protein such as 0.1% BSA.

Storage/Stability:

Upon receipt store at -20°C to -80°C. Upon reconstitution, store at 2-8°C for up to 1 week or in working aliquots at -20°C to -80°C.