Recombinant Human Heat Shock Protein 90-alpha, His tag

Synonyms:

HSP90A, Heat shock 86 kDa, HSP 86, HSP86, Lipopolysaccharide-associated protein 2, LAP-2, LPS-associated protein 2, Renal carcinoma antigen NY-REN-38

Species:

Human

Cat. No.:

CRH113C pdf (datasheet)

Quantity/Size:

1.0 mg

Price:

$4,500.00 BUY

Description:

Heat shock protein 90 (HSP90A) has been identified in the cytosol, nucleus and endoplasmic reticulum, and is reported to exist in many tissue types. In several tissues, including smooth muscle, HSP90A comprises up to 2% of total cellular protein. HSP90A functions as a dimer, assembled as part of heterocomplex. It possesses ATP-binding site and low ATPase activity. HSP90A is able to associate with actin filaments in certain conditions. Another important property of HSP90A is the binding of unoccupied steroid hormone receptors. HSP90A has been characterized as a molecular chaperone able to keep the target protein in a folding-competent state. It has an enhanced chaperone activity in oligomeric form at high temperatures. HSP90A function is sensitive to bivalent cations concentration.

Entrez Symbol:

HSP90AA1

Uniprot Name:

Heat shock protein HSP 90-alpha

Uniprot ID:

P07900

Data PDF:

CRH113

Source:

E. coli

Molecular Weight:

86.8 kDa (732 aa + N-terminal 20 aa His-tag)

Tag:

N-terminal 20 aa His-tag

Physical State:

Liquid

Formulation:

Sterile-filtered 20 mM Tris-HCl, 100 mM NaCl, pH 7.4

Purity:

> 90.0%, as determined by RP-HPLC and SDS-PAGE.

Amino Acid Sequence:

MGSSHHHHHH SSGLVPRGSH MPEETQTQDQ PMEEEEVETF AFQAEIAQLM SLIINTFYSN KEIFLRELIS NSSDALDKIR YESLTDPSKL DSGKELHINL IPNKQDRTLT IVDTGIGMTK ADLINNLGTI AKSGTKAFME ALQAGADISM IGQFGVGFYS AYLVAEKVTV ITKHNDDEQY AWESSAGGSF TVRTDTGEPM GRGTKVILHL KEDQTEYLEE RRIKEIVKKH SQFIGYPITL FVEKERDKEV SDDEAEEKED KEEEKEKEEK ESEDKPEIED VGSDEEEEKK DGDKKKKKKI KEKYIDQEEL NKTKPIWTRN PDDITNEEYG EFYKSLTNDW EDHLAVKHFS VEGQLEFRAL LFVPRRAPFD LFENRKKKNN IKLYVRRVFI MDNCEELIPE YLNFIRGVVD SEDLPLNISR EMLQQSKILK VIRKNLVKKC LELFTELAED KENYKKFYEQ FSKNIKLGIH EDSQNRKKLS ELLRYYTSAS GDEMVSLKDY CTRMKENQKH IYYITGETKD QVANSAFVER LRKHGLEVIY MIEPIDEYCV QQLKEFEGKT LVSVTKEGLE LPEDEEEKKK QEEKKTKFEN LCKIMKDILE KKVEKVVVSN RLVTSPCCIV TSTYGWTANM ERIMKAQALR DNSTMGYMAA KKHLEINPDH SIIETLRQKA EADKNDKSVK DLVILLYETA LLSSGFSLEDPQTHANRIYR MIKLGLGIDE DDPTADDTSA AVTEEMPPLE GDDDTSRMEE VD

Storage/Stability:

Store at 2-8°C