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Recombinant Human IGF-1 (Leu60) Receptor Grade

Molecule:

IGF-I

Species:

Human

Cat. No.:

ABU100 pdf (datasheet)

Quantity/Size:

100 μg

Price:

$290.00 BUY

Description:

Human [Leu60] IGF-I is an analogue of human IGF-I which has a Leucine substitution in place of Tyrosine at position 60 of the human IGF-I sequence. [Leu60]IGF-I has normal binding to acid-stripped human serum binding proteins but has reduced binding to the type 1 IGF receptor and to the insulin receptor compared to IGF-I. It is a useful analogue for studying the relative effects of IGF-I through the type 1 receptor and IGF binding proteins.

Entrez Symbol:

IGF1

Uniprot Name:

Insulin-like growth factor I

Uniprot ID:

P08069

Data PDF:

ABU020

Source:

E. coli

Molecular Weight:

7.6 kDa

Formulation:

Lyophilized from 0.1 M acetic acid

Purity:

> 95% by HPLC

Biological Activity:

Stimulates protein synthesis in rat L6 myoblasts: ED50 >2000 ng/ml IGF type 1 receptor binding assay: ED50 > 100 ng/ml IGF binding protein assay: ED50 < 10 ng/ml

Storage/Stability:

Store at 2-8°C.