Recombinant Human IGF-BP7

Synonyms:

IFGBP7, Insulin-like Growth Factor Binding Protein 7, Tumor-derived adhesion factor, TAF, MAC25 protein, Prostacyclin-stimulating factor

Species:

Human

Cat. No.:

CRI511B pdf (datasheet)

Quantity/Size:

25 μg

Price:

$520.00 BUY

Description:

IGF-BPs controls the distribution, function and activity of IGFs in various cell tissues and body fluids. Currently there are seven named IGF-BPs that form high affinity complexes with both IGF-I and IGF-II. IGF-BP7 is expressed in a wide range of normal human tissues and it generally shows reduced expression in cancer cell lines of prostate, breast, colon, and lung origin. It plays a role in skeletal myogenesis by binding to IGF in a manner that inhibits IGF induced differentiation of skeletal myoblasts, without affecting IGF induced proliferation. Additionally, IGF-BP7 suppresses growth and colony formation of prostate and breast cancer cell lines through an IGF independent mechanism, which causes a delay in the G1 phase of the cell cycle, and increased apoptosis.

Entrez Symbol:

IFGBP7

Uniprot ID:

Q16270

Data PDF:

CRI511B

Source:

E. coli

Molecular Weight:

26.4 kDa (256 aa)

Formulation:

Lyophilized from 5 mM sodium phosphate, pH 6.8

Purity:

> 98% by SDS-PAGE and HPLC analyses

Biological Activity:

Testing in progress

Endotoxin Level:

< 1 EU/µg

Amino Acid Sequence:

SSSDTCGPCE PASCPPLPPL GCLLGETRDA CGCCPMCARG EGEPCGGGGA GRGYCAPGME CVKSRKRRKG KAGAAAGGPG VSGVCVCKSR YPVCGSDGTT YPSGCQLRAA SQRAESRGEK AITQVSKGTC EQGPSIVTPP KDIWNVTGAQ VYLSCEVIGI PTPVLIWNKV KRGHYGVQRT ELLPGDRDNL AIQTRGGPEK HEVTGWVLVS PLSKEDAGEY ECHASNSQGQ ASASAKITVV DALHEIPVKK GEGAEL

Storage/Stability:

Stable for 1 year at -20°C to -80°C.