Recombinant Human Insulin-like Growth Factor I

Molecule:

IGF-I

Synonyms:

IGF-I, Somatomedin-C, Mechano growth factor, MGF

Species:

Human

Cat. No.:

CRI500C pdf (datasheet)

Quantity/Size:

1.0 mg

Price:

$295.00 BUY

Description:

Insulin-like growth factor 1 (IGF-I) is a member of the IGF family of mitogenic peptide growth factors, along with insulin and IGF-II. IGF-I stimulates proliferation and survival of various cell types including muscle, bone, and cartilage tissue. IGF-1 is produced primarily by the liver as an endocrine hormone as well as in target tissues in a paracrine/ autocrine fashion. The production of IGF-1 is stimulated by growth hormone (GH). Both IGF-I and IGF-II signal through the tyrosine kinase type I receptor (IGF-IR). Proteolytic processing of inactive precursor proteins, which contain N-terminal and C-terminal propeptide regions, generates mature IGFs.

Entrez Symbol:

IGF1

Uniprot Name:

Insulin-like growth factor I

Uniprot ID:

P05019

Data PDF:

CRI500

Source:

E. coli

Molecular Weight:

Monomer, 7.7 kDa (70 aa)

Formulation:

Lyophilized from a sterile filtered solution containing 0.1% Trifluoroacetic acid (TFA).

Purity:

>95% by reducing and non-reducing SDS-PAGE

Biological Activity:

ED50 < 10 ng/ml, determined by dose-dependent proliferation of mouse FDC-P1 cells. MCF-7 cell proliferation, typical ED50 = 7-15 ng/ml.

Specific Activity:

> 1.0 x 10e5 U/mg

Endotoxin Level:

< 1.0 EU/µg

Amino Acid Sequence:

GPETLCGAEL VDALQFVCGD RGFYFNKPTG YGSSSRRAPQ TGIVDECCFR SCDLRRLEMY CAPLKPAKSA

Storage/Stability:

Store as supplied at -20°C to -80°C for up to one year.