Synonyms:
IGF-BP2, Insulin-like growth factor-binding protein 2
Description:
IGF-BPs controls the distribution, function and activity of IGFs in various cell tissues and body fluids. Currently there are seven named IGF-BPs that form high affinity complexes with both IGF-I and IGF-II. IGF-BP2 is a cysteine-rich secreted protein produced by bone cells, and is most abundant in the brain. IGF-BP2 has been shown to inhibit IGF-II action
in human breast and ovarian carcinoma cells. Recombinant human IGF-BP2 consistS of 289 amino acid residues including the IGF-BP domain and thyroglobulin type-I domain.
Molecular Weight:
31.5 kDa (289 aa)
Formulation:
Lyophilized from PBS
Purity:
>98% by SDS-PAGE analysis.
Biological Activity:
Determined by its ability to inhibit IGF-I induced proliferation of FDC-P1 cells.
Amino Acid Sequence:
EVLFRCPPCT PERLAACGPP PVAPPAAVAA VAGGARMPCA ELVREPGCGC CSVCARLEGE ACQVYTPRCG QGLRCYPHPG SELPLQALVM GEGTCEKRRD AEYGASPEQV ADNGDDHSEG GLVENHVDST MNMLGGGGSA GRKPLKSGMK ELAVFREKVT EQHRQMGKGG KHHLGLEEPK KLRPPPARTP CQQELDQVLE RISTMRLPDE RGPLEHLYSL HIPNCDKHGL YNLKQCKMSL NGQRGECWCV NPNTGKLIQG APTIRGDPEC HLFYNEQQEA RGVHTQRMQ
Storage/Stability:
Stable for 1 year at -20°C to -80°C.
