Human Recombinant Insulin-like Growth Factor Binding Protein 3

Molecule:

IGFBP3

Synonyms:

IGFBP-3, IBP-3, IGF-binding protein 3

Species:

Human

Cat. No.:

BP3BU100 pdf (datasheet)

Quantity/Size:

100 μg

Price:

$770.00 BUY

Description:

Human Insulin-like growth factor binding protein-3 (IGFBP-3) is a 264 amino acid protein which is a member of a family of six circulating proteins that bind IGF-I and IGF-II with high affinity and modulate their metabolic and mitogenic effects. Human IGFBP-3 is a 40-44 kDa glycoprotein that is the most abundant IGFBP in serum and milk. It is produced by non-parenchymal hepatic cells and circulates in serum, binding IGF-I or IGF-II in conjunction with an acid labile subunit (ALS) to form a (1:1:1) 150 kDa circulating complex at a serum concentration of about 100 nM. Phosphorylation of IGFBP-3 also affects its biological activity.

Entrez Symbol:

IGFBP3

Uniprot Name:

Insulin-like Growth Factor Binding Protein 3

Uniprot ID:

P17936

Data PDF:

BP3BU020

Source:

Mammalian cells

Molecular Weight:

Glycosylated IGFBP-3: 43-45 kDa Non-glycosylated IGFBP-3: 28.76 kDa

Physical State:

Lyophilized

Formulation:

PBS

Purity:

> 95% by FPLC and SDS-PAGE Characteristic doublet of glycoforms detected by Western Ligand blotting

Endotoxin Level:

< 0.1 EU/µg

Storage/Stability:

Sore as supplied for up to 1 year at 2-8°C.