Recombinant Human IL-1 beta

Molecule:

IL-1 beta

Synonyms:

IL-1, Catabolin, IL-1 Beta, IL1F2

Species:

Human

Cat. No.:

CRI133A pdf (datasheet)

Quantity/Size:

2 μg

Price:

$85.00 BUY

Description:

Interleukin-1 beta (IL1β) is produced, mainly by activated macrophages, as a proprotein which is proteolytically processed to its active form by caspase 1. This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. Both IL-1 alpha and IL-1 beta bind to the same receptor and have similar but not identical biological properties. .

Entrez Symbol:

IL1B

Uniprot Name:

Interleukin-1 beta

Uniprot ID:

P01584

Data PDF:

CRI133

Source:

E. coli

Molecular Weight:

Monomer, 17.5 kDa (154 aa)

Physical State:

Lyophilized

Formulation:

Sterile filtered solution of 10 mM sodium phosphate, pH 7.5.

Purity:

>95% by reducing and non-reducing SDS-PAGE

Biological Activity:

ED50 < 1 pg/ml, determined by D10S cell proliferation.

Specific Activity:

≥ 8.3 x 10e7 units/mg

Endotoxin Level:

≤1 EUs/µg by kinetic LAL

Amino Acid Sequence:

MAPVRSLNCT LRDSQQKSLV MSGPYELKAL HLQGQDMEQQ VVFSMSFVQG EESNDKIPVA LGLKEKNLYL SCVLKDDKPT LQLESVDPKN YPKKKMEKRF VFNKIEINNK LEFESAQFPN WYISTSQAEN MPVFLGGTKG GQDITDFTMQ FVSS

Reconstitution:

Centrifuge vial prior to opening. Add sterile distilled water to a concentration of 0.1 mg/ml. DO NOT VORTEX. Allow several minutes for complete reconstitution.

Storage/Stability:

Store at -20 °C to -80 °C for up to 1 year.