Recombinant Human IL-17AF Heter mer

Species:

Human

Cat. No.:

CS307C pdf (datasheet)

Quantity/Size:

1 mg

Price:

$5,680.00 / Special Price: $3,720.00 BUY

Description:

Interleukin-17AF (IL-17AF) is a member of the IL-17 family of proteins produced by a subset of T cells, called Th17, following stimulation with IL-23. Since IL-17AF is thought to signal through the IL-17RA receptor, its biological function is similar to that of IL-17A in that it induces the production of a variety of chemokines, in addition to airway neutrophilia. In regard to these functions, IL-17AF has less activity than the IL-17A homodimer but, greater activity than the IL-17F homodimer. Human and rat IL-17AF both show activity on mouse cells. Recombinant human IL-17AF is a non-glycosylated heterodimer, containing an IL-17A subunit, 137 aa, an IL-17F subunit, 134 aa, for a total of 271 amino acids.

Entrez Symbol:

IL17A, IL17F

Uniprot ID:

Q16552, Q96PD4

Data PDF:

CS307

Source:

E. coli

Molecular Weight:

30.7 kDa

Physical State:

Lyophilized

Formulation:

Sterile filtered aqueous solution containing 0.1% Trifluoroacetic Acid (TFA)

Purity:

≥ 95 % determined by reducing and non-reducing SDS-PAGE

Biological Activity:

≤ 50 ng/ml, determined by a dose-dependent production of IL-6 in cultured mouse NIH 3T3 cells.

Specific Activity:

≥ 2.0 x 10e4 units/mg

Endotoxin Level:

≤ 1 EU/μg by kinetic LAL analysis

Amino Acid Sequence:

IL-17A: MIVKAGITIP RNPGCPNSED KNFPRTVMVN LNIHNRNTNT NPKRSSDYYN RSTSPWNLHR NEDPERYPSV IWEAKCRHLG CINADGNVDY HMNSVPIQQE ILVLRREPPH CPNSFRLEKI LVSVGCTCVT PIVHHVA IL-17F: MRKIPKVGHT FFQKPESCPP VPGGSMKLDI GIINENQRVS MSRNIESRST SPWNYTVTWD PNRYPSEVVQ AQCRNLGCIN AQ

Storage/Stability:

Store as supplied at -20°C to -80°C for up to 1 year.