Recombinant Human IL-17F

Molecule:

IL-17F

Synonyms:

IL-17F, ML-1, ML1

Species:

Human

Cat. No.:

CRI197C pdf (datasheet)

Quantity/Size:

1.0 mg

Price:

$2,720.00 / Special Price: $2,220.00 BUY

Description:

Interleukin-17F (IL17F) is synthesized as a 154 aa precursor with a 20 aa signal sequence and a 134 aa mature region. Like IL17A, IL17F contains one potential site for N-linked glycosylation. IL17A and IL17F share 50% aa sequence identity. IL17F homodimer is produced by an activated subset of CD4+ T cells, termed Th17. IL17F has been shown to stimulate proliferation and activation of T-cells and PBMCs. IL17F also regulates cartilage matrix turnover and inhibits angiogenesis. The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC. Involved in stimulating the production of other cytokines such as IL6, IL8 and CSF2.

Entrez Symbol:

IL17F

Uniprot ID:

Q96PD4

Data PDF:

CRI197

Source:

E. coli

Molecular Weight:

Disulfide linked dimer 15.0/30.1 kDa (134/268 aa)

Physical State:

Lyophilized

Formulation:

Sterile filtered aqueous solution containing 0.1% Trifluoroacetic Acid (TFA)

Purity:

> 95% by reducing and non-reducing SDS-PAGE

Biological Activity:

< 100 ng/ml, determined by production of IL-6 from murine NIH/3T3 cells.

Specific Activity:

> 1.0 × 10e4 U/mg.

Endotoxin Level:

< 0.1 EUs/μg by kinetic LAL

Amino Acid Sequence:

MRKIPKVGHT FFQKPESCPP VPGGSMKLDI GIINENQRVS MSRNIESRST SPWNYTVTWD PNRYPSEVVQ AQCRNLGCIN AQGKEDISMN SVPIQQETLV VRRKHQGCSV SFQLEKVLVT VGCTCVTPVI HHVQ

Storage/Stability:

Store as supplied at -20°C to -80°C for up to 1 year.