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Interleukin-17F (IL17F) is synthesized as a 154 aa precursor with a 20 aa signal sequence and a 134 aa mature region. Like IL17A, IL17F contains one potential site for N-linked glycosylation. IL17A and IL17F share 50% aa sequence identity. IL17F homodimer is produced by an activated subset of CD4+ T cells, termed Th17. IL17F has been shown to stimulate proliferation and activation of T-cells and PBMCs. IL17F also regulates cartilage matrix turnover and inhibits angiogenesis. The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC. Involved in stimulating the production of other cytokines such as IL6, IL8 and CSF2.
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