IL-17F

IL-17F, ML-1, ML1

Human

CRI197C-AF pdf (datasheet)

1.0 mg

$2,990.00 / Special Price: $2,370.00 BUY

Interleukin-17F (IL17F) is synthesized as a 154 aa precursor with a 20 aa signal sequence and a 134 aa mature region. Like IL17A, IL17F contains one potential site for N-linked glycosylation. IL17A and IL17F share 50% aa sequence identity. IL17F homodimer is produced by an activated subset of CD4+ T cells, termed Th17. IL17F has been shown to stimulate proliferation and activation of T-cells and PBMCs. IL17F also regulates cartilage matrix turnover and inhibits angiogenesis. The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC. Involved in stimulating the production of other cytokines such as IL6, IL8 and CSF2.

Manufactured without Animal-derived products, in an Animal Free facility.

IL17F

Interleukin-17F

Q96PD4

CRI197-AF

E. coli

Disulfide linked dimer 15.0/30.1 kDa (134/268 aa)

Lyophilized

Lyophilized from a sterile filtered aqueous solution containing 0.1% Trifluoroacetic Acid (TFA)

≥ 95% by reducing and non-reducing SDS-PAGE

≤ 100 ng/ml, determined by production of IL-6 from murine NIH/3T3 cells.

≥ 1.0 × 10e4

≤ 0.1 EUs/μg

MRKIPKVGHT FFQKPESCPP VPGGSMKLDI GIINENQRVS MSRNIESRST SPWNYTVTWD PNRYPSEVVQ AQCRNLGCIN AQGKEDISMN SVPIQQETLV VRRKHQGCSV SFQLEKVLVT VGCTCVTPVI HHVQ

Centrifuge vial prior to opening. Add sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Please note that the addition of any carrier protein into this product may produce unwanted endotoxin. This depends upon the particular application employed. Further dilutions should be made in appropriate buffered solutions.

Store as supplied at -20°C to -80°C for up to 1 year. Upon reconstitution, prepare working aliquots and store at -20°C to -80°C. It is recommended that a carrier protein such as 0.1% HSA or BSA is added for long term storage. Avoid repeated freeze-thaw cycles.