IL-21

Interleukin-21, Za11, IL-21

Human

CRI172C pdf (datasheet)

1.0 mg

$4,820.00 / Special Price: $3,940.00 BUY

Interleukin 21 (IL-21) is a member of the common-gamma chain family of cytokines with immunoregulatory activity. IL-21 plays a role in both the innate and adaptive immune responses by inducing the differentiation, proliferation and activity of multiple target cells including macrophages, natural killer (NK) cells, B cells and cytotoxic T cells. IL-21 is produced by CD4+ T cells in response to antigenic stimulation. Its action generally enhances antigen-specific responses of immune cells. IL-21 exerts its effect through binding to a specific type I cytokine receptor, IL-21R, which also contains the gamma chain (γc) found in other cytokine receptors. The IL-21R activates the JAK/STAT signaling pathway and is expressed on T, B, and NK cells. Within the B cell lineage, IL-21 is a switch factor regulating IgG1 and IgG3 antibody production. IL-21 also cooperates with IL-4 for the production of multiple antibody classes in B cells.

IL21

Interleukin-21

Q9HBE4

E. coli

15.4 kDa (132 aa)

Lyophilized

Lyophilized from sterile-filtered 10 mM sodium phosphate, pH 7.5.

>95% by reducing and non-reducing SDS-PAGE

ED₅₀ < 50 ng/ml, determined by dose-dependent proliferation of B9 cells.
ED₅₀ < 2.0 ng/ml, determined by dose-dependent proliferation of ANBL-6 cells.

＞ 2.0 × 10⁴ U/mg, determined by dose-dependent proliferation of B9 cells.
＞ 5.0 × 10⁵ U/mg, determined by dose-dependent proliferation of ANBL-6 cells.

≤1 EU/µg of protein by kinetic LAL analysis

QGQDRHMIRM RQLIDIVDQL KNYVNDLVPE FLPAPEDVET NCEWSAFSCF QKAQLKSANT GNNERIINVS IKKLKRKPPS TNAGRRQKHR LTCPSCDSYE KKPPKEFLER FKSLLQKMIH QHLSSRTHGS EDS

Centrifuge vial prior to opening. Add sterile distilled water to a concentration of 0.1 mg/ml. DO NOT VORTEX. Allow several minutes for complete reconstitution. Further dilutions should be made in appropriate buffered solutions.

Store at -20°C to -80°C for up to 1 year.