Recombinant Human IL-22

Molecule:

IL-22

Synonyms:

IL-TIF, TIFa, IL-10-related T-cell-derived-inducible factor, ILTIF, IL-D110, zcyto18

Species:

Human

Cat. No.:

CRI177C pdf (datasheet)

Quantity/Size:

1.0 mg

Price:

$4,820.00 / Special Price: $3,720.00 BUY

Description:

Interleukin 22 (IL-22), also called IL-TIF, is an IL-10 family member that is produced by activated dendritic cells and T lymphocytes. IL-22 signals via a heteroduplex receptor consisting of IL-22R and IL-10RB chains. IL-22 is a potent mediator of cellular inflammatory responses.

Entrez Symbol:

IL22

Uniprot ID:

Q9GZX6

Source:

E. coli

Molecular Weight:

Dimer, 16.9/33.8 kDa (147/294 aa)

Physical State:

Lyophilized

Formulation:

Sterile filtered aqueous solution containing 10 mM sodium citrate, pH 3.0

Purity:

> 95 % by reducing and non-reducing SDS-PAGE

Biological Activity:

This product demonstrates pSTAT3 activation in HepG2 cells, detected with western blot at 1-5 ng/ml.

Endotoxin Level:

< 1 EU/µg, by kinetic LAL

Amino Acid Sequence:

MAPISSHCRL DKSNFQQPYI TNRTFMLAKE ASLADNNTDV RLIGEKLFHG VSMSERCYLM KQVLNFTLEE VLFPQSDRFQ PYMQEVVPFL ARLSNRLSTC HIEGDDLHIQ RNVQKLKDTV KKLGESGEIK AIGELDLLFM SLRNACI

Reconstitution:

Centrifuge vial prior to opening to bring contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/ml. Further dilutions should be made in appropriate buffered solutions.

Storage/Stability:

Store as supplied, at -20°C to -80°C for up to 1 year.