Recombinant Human IL-31 Animal Free

Molecule:

IL-31

Synonyms:

IL-31

Species:

Human

Cat. No.:

CRI201C-AF pdf (datasheet)

Quantity/Size:

1.0 mg

Price:

$5,300.00 / Special Price: $4,320.00 BUY

Description:

Interleukin-31 is a T-cell derived cytokine that shares several structural and functional characteristics with IL-6, Oncostatin M, LIF, and Cardiotrophin-1. It signals through a receptor complex comprised of GPL (GP130-like, IL-31RA) and OSMR (Oncostatin M receptor). GPL/OSMR signaling is a strong activator of STAT3 and STAT5, and can also activate STAT1, Jak1, and Jak2 signaling pathways. IL-31 regulated immune responses have been implicated in skin physiology and inflammatory skin diseases.

Manufactured without animal-derived reagents in an Animal Free facility.

Uniprot Name:

Interleukin-31

Uniprot ID:

Q6EBC2

Data PDF:

CRI201-AF

Source:

E. coli

Molecular Weight:

15.8 kDa (141 aa) monomer

Formulation:

Lyophilized from a sterile filtered solution containing 20 mM sodium phosphate, 50 mM NaCl, pH 7.5

Purity:

≥ 95% by reducing and non-reducing SDS-PAGE

Biological Activity:

≤ 25 ng/ml, demonstrates STAT3 activation of U-87 MG cells.

Endotoxin Level:

≤ 1 EU/μg, determined by kinetic LAL analysis.

Amino Acid Sequence:

SHTLPVRLLR PSDDVQKIVE ELQSLSKMLL KDVEEEKGVL VSQNYTLPCL SPDAQPPNNI HSPAIRAYLK TIRQLDNKSV IDEIIEHLDK LIFQDAPETN ISVPTDTHEC KRFILTISQQ FSECMDLALK SLTSGAQQAT T

Reconstitution:

Centrifuge vial prior to opening. Add sterile distilled water to a concentration of 0.1 mg/mL and gently pipet the solution up and down the sides of the vial. DO NOT VORTEX. Allow several minutes for reconstitution. A small amount of precipitate may be seen.

Storage/Stability:

Store as supplied at -20°C to -80°C for up to 1 year. Upon reconstitution, prepare working aliquots and store at -20°C to -80°C. It is recommended that a carrier protein such as 0.1% HSA or BSA is added for long term storage. Avoid repeated freeze-thaw cycles.