Recombinant Human IL-4 Animal Free

Molecule:

IL-4

Synonyms:

IL-4, BCGF, BCDF, BSF-1, HCGF, MCGF-2, MFF, TCGF-2

Species:

Human

Cat. No.:

CRI104C-AF pdf (datasheet)

Quantity/Size:

1 mg

Price:

$4,020.00 / Special Price: $2,640.00 BUY

Description:

Interleukin-4 is a pleiotropic cytokine that regulates diverse T and B cell responses including cell proliferation, survival and gene expression. Produced by mast cells, T cells and bone marrow stromal cells, IL-4 regulates the differentiation of naive CD4+ T cells into helper Th2 cells. Another dominant function of IL-4 is the regulation of immunoglobulin class switching to the IgG1 and IgE isotypes. Excessive IL-4 production by Th2 cells has been associated with elevated IgE production and allergy. Recombinant Human IL-4 is a single, non-glycosylated polypeptide chain containing 130 amino acids.

Entrez Symbol:

IL4

Uniprot ID:

P05112

Data PDF:

CRI104-AF

Source:

E. coli

Molecular Weight:

Monomer, 15.1 kDa (130 aa)

Physical State:

Lyophilized

Formulation:

Sterile filtered solution containing 0.1% Trifluoroacetic Acid (TFA).

Purity:

≥95% by reducing and nonreducing SDS-PAGE

Biological Activity:

ED50 < 250 pg/ml, determined by cell proliferation of human TF-1 cells.

Specific Activity:

≥4.0 x 106 IU/mg, calibrated against rhIL-4 WHO International Standard (NIBSC code: 88/656).

Endotoxin Level:

≤1 EU/µg, kinetic LAL

Amino Acid Sequence:

MHKCDITLQE IIKTLNSLTE QKTLCTELTV TDIFAASKNT TEKETFCRAA TVLRQFYSHH EKDTRCLGAT AQQFHRHKQL IRFLKRLDRN LWGLAGLNSC PVKEANQSTL ENFLERLKTI MREKYSKCSS

Storage/Stability:

Upon receipt, store at -20°C to -80°C for up to 1 year.