Recombinant Human IL-4 Receptor

Molecule:

IL-4R

Synonyms:

CD124, IL4RA, IL-4 receptor subunit alpha, IL-4R subunit alpha, IL-4R-alpha, IL-4RA, interleukin-4 receptor alpha chain

Species:

Human

Cat. No.:

CRI181B pdf (datasheet)

Quantity/Size:

15 μg

Price:

$500.00 BUY

Description:

IL-4 can signal through type I and type II receptor complexes, which share a common gamma chain. The type I receptor contains, in addition to the gamma chain, an IL-4R alpha subunit, whereas the type II receptor contains the IL-13R alpha. The secreted extracellular domain of IL-4R alpha, called sIL-4R alpha, binds IL-4 and antagonizes its activity. It plays an important role in regulating the differentiation of naïve CD4+ T cells and class switching to IgG1 and IgE.

Entrez Symbol:

IL4R

Uniprot Name:

Interleukin-4 receptor subunit alpha

Uniprot ID:

P24394

Data PDF:

CRI181

Source:

CHO cells

Molecular Weight:

23.9 kDa (209 aa) predicted 50-65 kDa, apparent, under reducing conditions, due to glycosylation

Formulation:

Lyophilized from a sterile filtered solution without additives.

Purity:

>97% by SDS-PAGE and HPLC analyses

Biological Activity:

ED50: <5.0 ng/ml (as determined by its ability to inhibit the IL-4 dependent proliferation of human TF-1 in the presence of 0.5 ng/ml of IL-4).

Specific Activity:

> 2 x 10e5 units/mg

Endotoxin Level:

< 1 EU/ μg

Amino Acid Sequence:

GNMKVLQEPT CVSDYMSIST CEWKMNGPTN CSTELRLLYQ LVFLLSEAHT CIPENNGGAG CVCHLLMDDV VSADNYTLDL WAGQQLLWKG SFKPSEHVKP RAPGNLTVHT NVSDTLLLTW SNPYPPDNYL YNHLTYAVNI WSENDPADFR IYNVTYLEPS LRIAASTLKS GISYRARVRA WAQCYNTTWS EWSPSTKWHN SYREPFEQH

Storage/Stability:

Stable for 1 year at -20°C to -80°C.