IL-7

IL-7, Lymphopoietin, pre-B cell factor

Human

CRI108C-AF pdf (datasheet)

1 mg

$6,260.00 / Special Price: $4,100.00 BUY

IL-7 is a cytokine important for B and T cell development. This cytokine and the hepatocyte growth factor (HGF) form a heterodimer that functions as a pre-pro-B cell growth-stimulating factor. This cytokine is found to be a cofactor for V(D)J rearrangement of the T cell receptor beta (TCRB) during early T cell development. IL-7 is constitutively produced by stromal cells from the bone marrow and thymus and can be produced locally by intestinal epithelial and epithelial goblet cells, and may serve as a regulatory factor for intestinal mucosal lymphocytes. IL-7 signals through the IL-7R to promote the differentiation of hematopoietic stem cells to lymphoid precursor cells, which give rise to T cells, B cells, and natural killer cells. IL-7 can also co-stimulate the proliferation of mature T cells in combination with other factors such as ConA and IL-2. Human and mouse IL-7 show species cross-reactivity.

IL7

P13232

Monomer, 17.5 kDa (153 aa)

Lyophilized

Sterile filtered solution of 10mM acetic acid.

> 95% by reducing and non-reducing SDS-PAGE

ED50 ≤ 1 ng/ml, as determined by the dose-dependent stimulation of the proliferation of mouse 2E8 cells.

3.5 x 10e6 U/mg

≤ 1 EU/µg, kinetic LAL

MDCDIEGKDG KQYESVLMVS IDQLLDSMKE IGSNCLNNEF NFFKRHICDA NKEGMFLFRA ARKLRQFLKM NSTGDFDLHL LKVSEGTTIL LNCTGQVKGR KPAALGEAQP TKSLEENKSL KEQKKLNDLC FLKRLLQEIK TCWNKILMGT KEH

Store at -20 °C to -80 °C for up to 1 year.