Synonyms:
T-cell growth factor p40, P40 cytokine
Description:
Interleukin-9 (IL-9) is a cytokine that acts as a regulator of a variety of hematopoietic cells, and is produced by Th2-type CD4+ T cells. This cytokine stimulates cell proliferation, prevents apoptosis and supports the growth of IL-2- and IL-4-independent helper T-cells. It functions through the IL-9 receptor, which activates different signal transducer and activator (STAT) proteins and thus connects this cytokine to various biological processes. The IL-9 gene has been associated with asthma.
Molecular Weight:
14.3 kDa (127 aa)
Physical State:
Lyophilized
Formulation:
Sterile-filtered solution in 10 mM sodium phosphate, pH 7.5.
Purity:
>95%, by reducing and non-reducing SDS-PAGE.
Biological Activity:
ED50 < 2 ng/ml, as determined by a cell proliferation assay using human MO7e cells.
Specific Activity:
>5.0 × 105 U/mg
Endotoxin Level:
≤1 EU/µg of protein by kinetic LAL analysis
Amino Acid Sequence:
MQGCPTLAGI LDINFLINKM QEDPASKCHC SANVTSCLCL GIPSDNCTRP CFSERLSQMT NTTMQTRYPL IFSRVKKSVE VLKNNKCPYF SCEQPCNQTT AGNALTFLKS LLEIFQKEKM RGMRGKI
Storage/Stability:
Upon receipt, store at -20°C to -80°C for up to 1 year.
