Recombinant Human Interleukin-13

Molecule:

IL-13

Synonyms:

ALRH, BHR1, IL-13, NC30

Species:

Human

Cat. No.:

CRH064C pdf (datasheet)

Quantity/Size:

1.0 mg

Price:

$5,680.00 / Special Price: $3,720.00 BUY

Description:

Interleukin-13 (IL-13) is an important cytokine secreted from Th2 cells, mast cells and NK cells. IL-13 exerts anti-inflammatory effects on monocytes and macrophages and it inhibits the expression of inflammatory cytokines such as IL-1 beta, TNF-alpha, IL-6 and IL-8. IL-13 has also been shown to enhance B-cell proliferation and to induce isotype switching resulting in increased production of IgE. The receptor subunits of IL-13 consist of IL-4Rα, IL-13Rα1 and IL-13Rα2. Blocking of IL-13 activity inhibits the pathophysiology of asthma.

Entrez Symbol:

IL13

Uniprot ID:

P35225

Data PDF:

CRH064

Source:

E. coli

Molecular Weight:

12.6 kDa (115 aa)

Physical State:

Lyophilized

Formulation:

Sterile-filtered aqueous solution containing 10 mM sodium citrate, pH 3.0.

Purity:

> 95% by reducing and non-reducing SDS-PAGE

Biological Activity:

ED50 < 5 ng/ml, determined by a cell proliferation assay using human TF-1 cells.

Specific Activity:

> 2.0 × 10e5 U/mg

Endotoxin Level:

≤1 EU/µg of protein by kinetic LAL

Amino Acid Sequence:

MSPGPVPPST ALRELIEELV NITQNQKAPL CNGSMVWSIN LTAGMYCAAL ESLINVSGCS AIEKTQRMLS GFCPHKVSAG QFSSLHVRDT KIEVAQFVKD LLLHLKKLFR EGQFN

Storage/Stability:

Store as supplied at -20°C to -80°C for up to 1 year.