Recombinant Human Interleukin 34

Synonyms:

IL-34, C16orf77

Species:

Human

Cat. No.:

CRA028A pdf (datasheet)

Quantity/Size:

10 μg

Price:

$375.00 BUY

Description:

IL-34 is a homodimeric cytokine that is expressed in a range of tissues including spleen, heart, brain, liver, kidney, lung, ovary, thymus, testis, small intestine, prostate and colon. IL-34 is a ligand for colony-stimulating factor-1 receptor (CSF1R), which also binds to CSF-1. It specifically binds CD14+ monocytes, promotes survival and proliferation of human peripheral blood monocytes, and stimulates macrophage colony formation by human bone marrow cells. IL-34, like human CSF-1 stimulates phosphorylation of MAPK1/ERK2 and MAPK3/ERK1.

Entrez Symbol:

IL34

Uniprot ID:

Q6ZMJ4

Data PDF:

CRA028

Source:

HEK293 cells

Molecular Weight:

52.5 kDa (460 aa) dimer

Physical State:

Lyophilized

Formulation:

Sterile filtered solution containing 20 mM citric acid, pH 3.0

Purity:

> 98% by SDS-PAGE

Biological Activity:

This product demonstrates dose-dependent induced secretion of MCP-1 from PBMCs.

Endotoxin Level:

≤1 EU/µg

Amino Acid Sequence:

NEPLEMWPLT QNEECTVTGF LRDKLQYRSR LQYMKHYFPI NYKISVPYEG VFRIANVTRL QRAQVSEREL RYLWVLVSLS ATESVQDVLL EGHPSWKYLQ EVETLLLNVQ QGLTDVEVSP KVESVLSLLN APGPNLKLVR PKALLDNCFR VMELLYCSCC KQSSVLNWQD CEVPSPQSCS PEPSLQYAAT QLYPPPPWSP SSPPHSTGSV RPVRAQGEGL LPHHHHHHHH

Reconstitution:

Centrifuge vial prior to opening. Reconstitute in sterile deionized water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for 1 week.

Storage/Stability:

Store at -20°C to -80°C for up to 1 year.