Synonyms:
LIF, CDF, DIA, HILDA, MLPLI
Description:
Leukemia Inhibitory Factor (LIF) is a member of the IL-6 family and a pleiotropic cytokine with roles in several different systems. It is involved in the induction of hematopoietic differentiation in normal and myeloid leukemia cells, induction of neuronal cell differentiation, regulator of mesenchymal to epithelial conversion during kidney development, and may also have a role in immune tolerance at the maternal-fetal interface.
Uniprot Name:
Leukemia inhibitory factor
Molecular Weight:
19.9 kDa (181 aa)
Physical State:
Lyophilized
Formulation:
Lyophilized from a sterile filtered aqueous solution containing 0.1% Trifluoroacetic Acid (TFA).
Purity:
> 95% by reducing and non-reducing SDS-PAGE
Biological Activity:
ED50 < 200 pg/ml, determined by TF-1 cell proliferation.
Specific Activity:
≥ 5.0 x 10e6 U/mg
Endotoxin Level:
≤1 EU/µg of protein by kinetic LAL analysis
Amino Acid Sequence:
MSPLPITPVN ATCAIRHPCH NNLMNQIRSQ LAQLNGSANA LFILYYTAQG EPFPNNLDKL CGPNVTDFPP FHANGTEKAK LVELYRIVVY LGTSLGNITR DQKILNPSAL SLHSKLNATA DILRGLLSNV LCRLCSKYHV GHVDVTYGPD TSGKDVFQKK KLGCQLLGKY KQIIAVLAQA F
Storage/Stability:
Store as supplied at -20°C to -80°C for up to 1 year.
