Recombinant Human MIF

Molecule:

MIF

Synonyms:

Macrophage migration inhibitory factor, Glycosylation-inhibiting factor, GIF

Species:

Human

Cat. No.:

CRH318C pdf (datasheet)

Quantity/Size:

1.0 mg

Price:

$2,720.00 / Special Price: $2,100.00 BUY

Description:

Macrophage migration inhibitory factor (MIF) is a pro-inflammatory lymphokine that functions during cell-mediated immmunity. MIF promotes fibroblast migration by inducing interleukin 1 (IL-1), interleukin 8 (IL-8), and matrix metalloproteinase (MMP) expression. In interferon-gamma-activated macrophages, MIF stimulates nitric oxide (NO) production and tumor necrosis factor-alpha (TNF-α) secretion.

Entrez Symbol:

MIF

Uniprot Name:

Macrophage migration inhibitory factor

Uniprot ID:

P14174

Data PDF:

CRH318

Source:

E. coli

Molecular Weight:

Monomer, 12.5 kDa (115 aa)

Formulation:

Lyophilized from a sterile-filtered solution containing 10 mM sodium phosphate, pH 7.5

Purity:

≥95% by reducing and non-reducing SDS-PAGE

Biological Activity:

This product demonstrates dose-dependent induction of IL-8 in human PBMCs. No acceptance criteria established.

Endotoxin Level:

≤1 EU/µg by kinetic LAL analysis

Amino Acid Sequence:

MPMFIVNTNV PRASVPDGFL SELTQQLAQA TGKPPQYIAV HVVPDQLMAF GGSSEPCALC SLHSIGKIGG AQNRSYSKLL CGLLAERLRI SPDRVYINYY DMNAANVGWN NSTFA

Storage/Stability:

Store as supplied at -20°C to -80°C for up to 1 year.