Recombinant Human MMP13

Molecule:

MMP13

Synonyms:

MMP13, Collagenase 3, CLG3, MANDP1

Species:

Human

Cat. No.:

CRM013B pdf (datasheet)

Quantity/Size:

10 μg

Price:

$300.00 BUY

Description:

Matrix Metalloproteinase-13 (MMP-13) is an enzyme that is a member of the MMP extracellular protease family. Extracellular protease enzymes, by virtue of their broad substrate specificities1, play a role in both normal and disease states of tissue proliferation. Among the targets of MMP-13 are collagen, gelatin, entactin, pro-TNF-a, and chemokine SDF-11-4. MMP-13 is found in its latent form as a 52-56 kDa glycosylated proenzyme. Upon cleavage the 22-46 kDa5 MMP-1 becomes active in extracellular matrix remodeling. Because of the prominent role that MMP-1 plays in cell migration and metastasis, it is an important target for inhibition screening.

Concentration:

0.5 mg/ml

Entrez Symbol:

MMP13

Uniprot Name:

Collagenase 3

Uniprot ID:

P45452

Data PDF:

CRM013

Source:

E. coli

Molecular Weight:

44. 7 kDa

Physical State:

Sterile filtered solution

Formulation:

20 mM Tris-HCl, pH 8.0, 0,15 M NaCl, 1 mM DTT.

Purity:

> 90% as determined by SDS-PAGE.

Amino Acid Sequence:

MGSSHHHHHH SSGLVPRGSH MGSYNVFPRT LKWSKMNLTY RIVNYTPDMT HSEVEKAFKK AFKVWSDVTP LNFTRLHDGI ADIMISFGIK EHGDFYPFDG PSGLLAHAFP PGPNYGGDAH FDDDETWTSS SKGYNLFLVA AHEFGHSLGL DHSKDPGALM FPIYTYTGKS HFMLPDDDVQ GIQSLYGPGD EDPNPKHPKT PDKCDPSLSL DAITSLRGET MIFKDRFFWR LHPQQVDAEL FLTKSFWPEL PNRIDAAYEH PSHDLIFIFR GRKFWALNGY DILEGYPKKI SELGLPKEVK KISAAVHFED TGKTLLFSGN QVWRYDDTNH IMDKDYPRLI EEDFPGIGDK VDAVYEKNGY IYFFNGPIQF EYSIWSNRIV RVMPANSILW C.

Storage/Stability:

Store at -20°C to -80°C.