Recombinant Human Myostatin Propeptide

Synonyms:

Growth Differentiation Factor 8, GDF8, GDF-8, MSLHP, MSTN

Species:

Human

Cat. No.:

CRM142C pdf (datasheet)

Quantity/Size:

1.0 mg

Price:

$4,820.00 / Special Price: $3,740.00 BUY

Description:

Myostatin (GDF-8) is a member of the TGF-β superfamily and is a potent and specific negative regulator of skeletal muscle mass. The myostatin propeptide is known to bind and inhibit myostatin in vitro. This interaction is relevant in vivo, with a majority (>70%) of myostatin in serum bound to its propeptide acting as a negative regulator of myostatin. Propeptide consists of Asn24-Arg266.

Entrez Symbol:

MSTN

Uniprot Name:

Growth/differentiation factor 8

Uniprot ID:

O14793

Source:

E. coli

Molecular Weight:

27.8 kDa (244 aa)

Formulation:

Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 0.1% Trifluoroacetic Acid (TFA)

Purity:

≥95.0%, determined by reducing and non-reducing SDS-PAGE

Endotoxin Level:

≤1 EUs/µg, by kinetic LAL

Amino Acid Sequence:

MNENSEQKEN VEKEGLCNAC TWRQNTKSSR IEAIKIQILS KLRLETAPNI SKDVIRQLLP KAPPLRELID QYDVQRDDSS DGSLEDDDYH ATTETIITMP TESDFLMQVD GKPKCCFFKF SSKIQYNKVV KAQLWIYLRP VETPTTVFVQ ILRLIKPMKD GTRYTGIRSL KLDMNPGTGI WQSIDVKTVL QNWLKQPESN LGIEIKALDE NGHDLAVTFP GPGEDGLNPF LEVKVTDTPK RSRR

Reconstitution:

Centrifuge vial prior to opening. When reconstituting the product, gently pipet and wash down the sides of the vial to ensure full recovery of the protein into solution. It is recommended to reconstitute the lyophilized product with sterile 20 mM HCl at a concentration of 0.1 mg/ml, which can be further diluted into other aqueous solutions.

Storage/Stability:

Store as supplied at -20°C to -80°C. Upon reconstitution, prepare working aliquots and store at -20°C to -80°C. It is recommended that a carrier protein (0.1% HSA or BSA) is added for long term storage. Avoid repeated freeze-thaw cycles.