Recombinant Human Myostatin

Synonyms:

Growth/differentiation factor 8, GDF-8

Species:

Human

Cat. No.:

CRMY00C pdf (datasheet)

Quantity/Size:

1.0 mg

Price:

$4,820.00 / Special Price: $3,720.00 BUY

Description:

Myostatin is a member of the TGF-beta superfamily that is essential for proper regulation of skeletal muscle mass in a number of species ranging from fish to humans. Myostatin is a secreted protein that negatively regulates skeletal muscle mass determining both muscle fiber number and size. Inhibition of myostatin can increase muscle mass in a number of animal models of human disease, including muscular dystrophy. Recombinant human Myostatin is a non-glycosylated homodimer, containing two 109 amino acid chains.

Entrez Symbol:

MSTN

Uniprot Name:

Growth/differentiation factor 8

Uniprot ID:

O14793 (Asp267-Ser375)

Source:

E. coli

Molecular Weight:

12.4/24.8 kDa (109/218 aa)

Physical State:

Lyophilized

Formulation:

Sterile-filtered solution containing 0.1% Trifluoroacetic (TFA)

Purity:

≥ 95% by reducing and non-reducing SDS-PAGE

Biological Activity:

< 50 ng/ml determined by cytotoxicity of MPC-11 cells

Specific Activity:

≥ 2.0 x 10e4 units/mg

Endotoxin Level:

≤ 1 EU/μg, by kinetic LAL analysis

Amino Acid Sequence:

DFGLDCDEHS TESRCCRYPL TVDFEAFGWD WIIAPKRYKA NYCSGECEFV FLQKYPHTHL VHQANPRGSA GPCCTPTKMS PINMLYFNGK EQIIYGKIPA MVVDRCGCS

Storage/Stability:

Store as supplied at -20°C to -80°C for up to 1 year.