Recombinant Human NAP-2/CXCL7

Molecule:

CXCL7

Synonyms:

Neutrophil-Activating Peptide 2, Platelet Basic Protein, PPBP, CXCL7, B-TG1, CTAP3, SCYB7

Species:

Human

Cat. No.:

CRN600C pdf (datasheet)

Quantity/Size:

1 mg

Price:

$2,720.00 / Special Price: $2,100.00 BUY

Description:

Neutrophil Activating Peptide 2 (NAP-2) is proteolytically processed carboxyl-terminal fragments of platelet basic protein (PBP) which is found in the alpha-granules of human platelets. NAP-2 is a member of the CXC chemokines. Similar to other ELR domain containing CXC chemokines such as IL-8 and the GRO proteins, NAP-2 has been shown to bind CXCR-2 and to chemoattract and activate neutrophils. Although CTAP-III, beta-TG and PBP represent amino-terminal extended variants of NAP-2 and possess the same CXC chemokine domains, these proteins do not exhibit NAP-2 activity. Recently, it has been shown that the additional amino-terminal residues of CTAP-III masks the critical ELR receptor binding domain that is exposed on NAP-2 and may account for lack of NAP-2 activity.

Entrez Symbol:

PPBP

Uniprot Name:

Platelet basic protein

Uniprot ID:

P02775

Data PDF:

CRN600

Source:

E. coli

Molecular Weight:

Monomer, 7.6 kDa (70 amino acids)

Physical State:

Lyophilized

Formulation:

Sterile (0.2 micron) filtered aqueous solution containing 10 mM sodium phosphate, pH 7.5

Purity:

> 95% by reducing and non-reducing SDS-PAGE

Endotoxin Level:

< 1 EU/μg by kinetic LAL analysis.

Amino Acid Sequence:

AELRCMCIKT TSGIHPKNIQ SLEVIGKGTH CNQVEVIATL KDGRKICLDP DAPRIKKIVQ KKLAGDESAD

Storage/Stability:

Store as supplied at -20°C to -80°C for up to 1 year.