Recombinant Human Neurturin

Synonyms:

NRTN. NTN

Species:

Human

Cat. No.:

CRN100A pdf (datasheet)

Quantity/Size:

20 μg

Price:

$520.00 BUY

Description:

Neurturin is a disulfide-linked homodimer neurotrophic factor structurally related to GDNF, Artemin, and Persephin. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. Neurturin signals through a multicomponent receptor system, composed of RET and one of four GFR α (α1-α4) receptors. Neurturin promotes the development and survival of sympathetic and sensory neurons by signaling through a receptor system composed of RET and GFRα2. The functional form of human Neurturin is a disulfide-linked homodimer, of two 11.8 kDa polypeptide monomers (204 total amino acid residues). Each monomer contains seven conserved cysteine residues, one of which (Cys 69) is used for inter-chain disulfide bridging and the others are involved in intramolecular ring formation known as the cysteine knot configuration.

Entrez Symbol:

NRTN

Uniprot ID:

Q99748

Data PDF:

CRN100A

Source:

E. coli

Molecular Weight:

11.8 kDa (204 aa) monomer

Formulation:

Lyophilized from PBS

Purity:

> 98% by SDS-PAGE and HPLC analyses.

Biological Activity:

Human Neurturin at a concentration of 50-100 ng/ml will support the survival of 65% of newborn rat sympathetic neurons.

Endotoxin Level:

< 1 EU/ug

Amino Acid Sequence:

ARLGARPCGL RELEVRVSEL GLGYASDETV LFRYCAGACE AAARVYDLGL RRLRQRRRLR RERVRAQPCC RPTAYEDEVS FLDAHSRYHT VHELSARECA CV

Storage/Stability:

Stable for 1 year at -20°C to -80°C.