Recombinant Human NP-1

Synonyms:

Neutrophil defensin 1, Defensin alpha 1, HNP-1

Species:

Human

Cat. No.:

CRN400B pdf (datasheet)

Quantity/Size:

20 μg

Price:

$520.00 BUY

Description:

Defensins (alpha and beta) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system. The α-defensins which include NP-1, NP-2 and NP-3, are distinguished from the ß-defensins by the pairing of their three disulfide bonds. In addition to antimicrobial activity, NP-1 exhibits chemotactic activity on dendritic cells. NP-1 is expressed as the C-terminal portion of an inactive precursor protein, which also contains a 19 amino acid N-terminal signal sequence and a 45 amino acid polypeptide. NP-1 contains a six-cysteine motif that forms three intramolecular disulfide bonds.

Entrez Symbol:

DEFA1

Uniprot Name:

Neutrophil defensin 1

Uniprot ID:

P59665

Data PDF:

CRN400

Source:

E. coli

Molecular Weight:

3.4 kDa (30 aa)

Physical State:

Lyophilized

Formulation:

Lyophilized from PBS.

Purity:

> 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity:

Determined by its ability to chemoattract immature dendritic cells using a concentration range of 1.0-10.0 ng/ml.

Endotoxin Level:

< 1 EU/µg

Storage/Stability:

Store as supplied at -20°C to -80°C for up to 1 year.