Synonyms:
Neutrophil defensin 1, Defensin alpha 1, HNP-1
Description:
Defensins (alpha and beta) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system. The α-defensins which include NP-1, NP-2 and NP-3, are distinguished from the ß-defensins by the pairing of their three disulfide bonds. In addition to antimicrobial activity, NP-1 exhibits chemotactic activity on dendritic cells. NP-1 is expressed as the C-terminal portion of an inactive precursor protein, which also contains a 19 amino acid N-terminal signal sequence and a 45 amino acid polypeptide. NP-1 contains a six-cysteine motif that forms
three intramolecular disulfide bonds.
Uniprot Name:
Neutrophil defensin 1
Molecular Weight:
3.4 kDa (30 aa)
Physical State:
Lyophilized
Formulation:
Lyophilized from PBS.
Purity:
> 98% by SDS-PAGE gel and HPLC analyses.
Biological Activity:
Determined by its ability to chemoattract immature dendritic cells using a concentration range of 1.0-10.0 ng/ml.
Endotoxin Level:
< 1 EU/µg
Storage/Stability:
Store as supplied at -20°C to -80°C for up to 1 year.
