Recombinant Human/Mouse Neurotrophin 3

Molecule:

NTF3

Synonyms:

Neurotrophic factor, Nerve growth factor-2, NGF-2, HDNF, NT3

Species:

Human

Cat. No.:

CRN500B pdf (datasheet)

Quantity/Size:

10 μg

Price:

$235.00 BUY

Description:

Neurotrophin-3 (NTF3) is an important member of the nerve growth factor (NGF) family of proteins behind BDNF and NGF. It is thought to promote the survival or differentiation of existing and new neurons in the central nervous system and synapses. These functions are thought to be communicated by TrkC, a receptor tryrosine kinase thought induce NTF3-specific signaling. In addition, NTF3 is thought to also bind TrkB and low affinity nerve growth factor receptor (LNGFR). Recombinant Human and mouse NTF3 have 100% sequence homology, composed of non-glycosylated, non-covalently linked homodimer containing two 120 amino acid chains.

Entrez Symbol:

NTF3

Uniprot Name:

Neurotrophin-3

Uniprot ID:

P20783 human, P20181 mouse

Data PDF:

CRN500

Source:

E. coli

Molecular Weight:

Dimer (noncovalently linked), 13.8/27.5 kDa (120/240 aa)

Physical State:

Lyophilized

Formulation:

Sterile filtered solution containing 0.1% Trifluoroacetic Acid (TFA).

Purity:

>95% by reducing and non-reducing SDS-PAGE

Biological Activity:

This product demonstrates induced proliferation with rat C6 cells.

Endotoxin Level:

< 1 EU/µg by kinetic LAL

Amino Acid Sequence:

MYAEHKSHRG EYSVCDSESL WVTDKSSAID IRGHQVTVLG EIKTGNSPVK QYFYETRCKE ARPVKNGCRG IDDKHWNSQC KTSQTYVRAL TSENNKLVGW RWIRIDTSCV CALSRKIGRT

Storage/Stability:

Store as supplied at -20 °C to -80 °C for up to one year.