Recombinant Human NT-4

Molecule:

NTF4

Synonyms:

Neurotrophin-4, Neurotrophin 5, NT-5, Neurotrophic Factor 4

Species:

Human

Cat. No.:

CRH321C pdf (datasheet)

Quantity/Size:

1.0 mg

Price:

$4,820.00 / Special Price: $4,060.00 BUY

Description:

Neurotrophin-4 (NT-4) is an important member of the nerve growth factor (NGF) family of proteins. Neurotrophins undergo paracrine and autocrine signaling to control neuronal survival, neuronal differentiation, and dendrite outgrowth. NT-4 is expressed ubiquitously and signals through the TrkB receptor tryrosine kinase.

Uniprot Name:

Neurotrophin-4

Uniprot ID:

P34130

Data PDF:

CRH321

Source:

E. coli

Molecular Weight:

14.1/28.1 kDa, (131/262 aa) noncovalant homodimer

Formulation:

Lyophilized from a sterile-filtered solution containing 0.1% Trifluoroacetic Acid

Purity:

≥95% by reducing and non-reducing SDS-PAGE

Biological Activity:

ED50 < 20 ng/ml by dose-dependent  proliferation of a neuroblastoma cell line stably expressing TrkB (BR6).

Specific Activity:

> 5.0 x 104 units/mg

Endotoxin Level:

≤1 EU/µg by kinetic LAL analysis

Amino Acid Sequence:

MGVSETAPAS RRGELAVCDA VSGWVTDRRT AVDLRGREVE VLGEVPAAGG SPLRQYFFET RCKADNAEEG GPGAGGGGCR GVDRRHWVSE CKAKQSYVRA LTADAQGRVG WRWIRIDTAC VCTLLSRTGR A

Storage/Stability:

Store as supplied at -20°C to -80°C for up to 1 year. Upon reconstitution, the preparation is stable for up to one month at 2-8°C. For long term storage reconstitute in working aliquots containing 0.1% BSA and store at -80°C. Avoid repeated freeze-thaw cycles.