Recombinant Human Oncostatin M Animal Free

Synonyms:

OSM

Species:

Human

Cat. No.:

CRH323C-AF pdf (datasheet)

Quantity/Size:

1 mg

Price:

$6,260.00 / Special Price: $4,100.00 BUY

Description:

Oncostatin M is a cytokine that is produced by macrophages, dendritic cells, and T lymphocytes during inflammatory events. The Type-I and Type-II Oncostatin M receptors are located on the cell surface of endothelial and tumor cells, contain the glycoprotein 130 (gp130) subunit, and activate the JAK/STAT signaling pathway. Oncostatin M functions to inhibit tumor cell proliferation, induce liver stem cell maturation, regulate cytokine production during hematopoiesis and inflammation, stimulate bone formation, and promote nervous system development.

Manufactured without Animal-derived products, in an Animal Free facility.

Entrez Symbol:

OSM

Uniprot Name:

Oncostatin-M

Uniprot ID:

P13725

Data PDF:

CRH323-AF

Source:

E. coli

Molecular Weight:

Monomer, 23.8 kDa (210 aa)

Physical State:

Lyophilized

Formulation:

Sterile-filtered solution containing 10 mM sodium phosphate, pH 7.5

Purity:

≥95% by reducing and non-reducing SDS-PAGE

Biological Activity:

ED50 < 4 ng/ml, determined by the ability to induce proliferation of TF-1 cells.

Specific Activity:

≥2.5 x 10e5 U/mg

Endotoxin Level:

≤1 EU/µg by kinetic LAL analysis

Amino Acid Sequence:

MAAIGSCSKE YRVLLGQLQK QTDLMQDTSR LLDPYIRIQG LDVPKLREHC RERPGAFPSE ETLRGLGRRG FLQTLNATLGCVLHRLADLE QRLPKAQDLE RSGLNIEDLE KLQMARPNIL GLRNNIYCMA QLLDNSDTAE PTKAGRGASQ PPTPTPASDA FQRKLEGCRFLHGYHRFMHS VGRVFSKWGE SPNRSRRHSP HQALRKGVRR

Storage/Stability:

Store as supplied at -20°C to -80°C for up to 1 year.