Recombinant Human PD-1/CD279:Fc Chimera

Species:

Human

Cat. No.:

CRH046 pdf (datasheet)

Quantity/Size:

100 μg

Price:

$526.00 BUY

Description:

CD279 (Programmed Cell Death Protein 1; PD-1) is a type I transmembrane protein belonging to the CD28/CTLA-4 family of immunoreceptors that mediate signals for regulating immune responses. Members of the CD28/CTLA-4 family have been shown to either promote T cell activation (CD28 and ICOS) or downregulate T cell activation (CTLA-4 and PD-1). CD279 is expressed on activated T cells, B cells, myeloid cells and on a subset of thymocytes. In vitro, ligation of CD279 inhibits TCR-mediated T cell proliferation and production of IL-1, IL-4, IL-10 and IFN-γ. In addition, CD279 ligation also inhibits BCR mediated signaling. CD279 deficient mice have a defect in peripheral tolerance and spontaneously develop autoimmune diseases. The extracellular domain of human CD279 [PD-1] (aa 25-167) is fused to the N-terminus of the Fc region of human IgG1.

Data PDF:

CRH046

Source:

CHO cells

Formulation:

Lyophilized from a 0.2 µm filtered solution containing PBS

Purity:

≥98% (SDS-PAGE)

Endotoxin Level:

<0.06 EU/µg purified protein as determined by LAL test (Lonza)

Storage/Stability:

Store at -20°C