Recombinant Human PDGF-AA

Synonyms:

PDGF-A, PDGF1, PDGF A-chain, platelet-derived growth factor alpha.

Species:

Human

Cat. No.:

CRP300C pdf (datasheet)

Quantity/Size:

1.0 mg

Price:

$3,520.00 / Special Price: $2,720.00 BUY

Description:

Platelet-Derived Growth Factor (PDGF) plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal lung alveolar septum formation during embryogenesis, normal development of the gastrointestinal tract, normal development of Leydig cells and spermatogenesis. Required for normal oligodendrocyte development and normal myelination in the spinal cord and cerebellum.The synthesis of PDGF can be induced by IL-1, IL-6, TNF-alpha, TGF-beta and EGF. PDGF is a dimeric glycoprotein formed by two A chains (AA), two B chains (BB), or as a heterodimer with an A and a B chain (AB). The PDGF dimer binds the cell surface receptor tyrosine kinases PDGFR-α and PDGFR-β.

Entrez Symbol:

PDGFA

Uniprot Name:

Platelet-derived growth factor subunit A

Uniprot ID:

P04085

Data PDF:

CRP300

Source:

E. coli

Molecular Weight:

Dimer, 14.4/28.9 kDa (126/252 aa)

Physical State:

Lyophilized

Formulation:

Sterile filtered solution containing 0.1% Trifluoroacetic Acid (TFA)

Purity:

≥ 95% by reducing and non-reducing SDS-PAGE

Biological Activity:

ED50 ≤50 ng/ml, determined by the dose-dependent proliferation of mouse 3T3 cells.

Specific Activity:

≥ 2.0 x 10e4 units/mg

Endotoxin Level:

≤ 1 EU/μg by kinetic LAL

Amino Acid Sequence:

MSIEEAVPAV CKTRTVIYEI PRSQVDPTSA NFLIWPPCVE VKRCTGCCNT SSVKCQPSRV HHRSVKVAKV EYVRKKPKLK EVQVRLEEHL ECACATTSLN PDYREEDTGR PRESGKKRKR KRLKPT

Storage/Stability:

Store as supplied at -20°C to -80°C for up to 1 year.