Recombinant Human PDGF-BB

Molecule:

PDGFBB

Synonyms:

PDGF-2, PDGF2, SIS, SSV, IBGC5, c-sis, GDGF, ODGF

Species:

Human

Cat. No.:

CRP302C pdf (datasheet)

Quantity/Size:

1.0 mg

Price:

$3,520.00 / Special Price: $2,720.00 BUY

Description:

Platelet-Derived Growth Factor (PDGF) is a member of the protein family which includes vascular endothelial growth factors (VEGF). PDGF is proteolytically processed from a pre/pro-protein to generate PDGF subunit B, which can homodimerize, or can heterodimerize with the related PDGF subunit A. These proteins bind and activate PDGF receptor tyrosine kinases. PDGF is a mitogenic peptide growth hormone carried in the alpha-granules of platelets, released when platelets adhere to traumatized tissues. Connective tissue cells near the traumatized region respond by initiating the process of replication. The synthesis of PDGF can be induced by IL-1, IL-6, TNF-α, TGF-β and EGF.

Entrez Symbol:

PDGFB

Uniprot Name:

Platelet-derived growth factor subunit B

Uniprot ID:

P01127

Data PDF:

CRP302

Source:

E. coli

Molecular Weight:

Dimer, 12.4/24.9 kDa (110/220 aa)

Physical State:

Lyophilized

Formulation:

Sterile filtered solution with 10 mM sodium phosphate, pH 7.5

Purity:

≥95.0% by reducing and non-reducing SDS-PAGE

Biological Activity:

ED50 < 20 ng/ml, determined by the dose-dependant proliferation of 3T3 cells.

Specific Activity:

> 5.0 x 10e4 IU/mg, calibrated against the International Standard, NIBSC code: 94/728.

Endotoxin Level:

< 1 EU/µg by kinetic LAL

Amino Acid Sequence:

MSLGSLTIAE PAMIAECKTR TEVFEISRRL IDRTNANFLV WPPCVEVQRC SGCCNNRNVQ CRPTQVQLRP VQVRKIGIVR KKPIFKKATV TLGDHLACKC ETVAAARPVT

Storage/Stability:

Store as supplied at -20°C to -80°C for up to 1 year.