Recombinant Human Placenta Growth Factor 3

Molecule:

PGF

Synonyms:

PlGF-3

Species:

Human

Cat. No.:

CRH067C pdf (datasheet)

Quantity/Size:

1.0 mg

Price:

$2,720.00 / Special Price: $2,120.00 BUY

Description:

PlGF, a member of the VEGF family, was originally discovered in the placenta, where it was proposed to regulate vascular development and trophoblast growth and differentiation. PlGF stimulates endothelial cell growth, migration, and survival and plays a central role in pathologic angiogenesis, including in cancer and tissue ischemia. PlGF concentrations increase throughout pregnancy, peaking during the third trimester, and falling thereafter, probably as a consequence of placental maturation. Despite interest in the utility of PlGF for clinical diagnostics, the role of PlGF in preeclampsia and in placental development is not well understood. PlGF is secreted as a homodimer and may also form a heterodimer with VEGF. There are four alternatively spliced PlGF isoforms (PlGF-1, PlGF-2, PlGF-3, and PlGF-4), each with unique secretion patterns and heparin-binding affinities. PlGF-3 lacks a heparin-binding domain and signals through the VEGFR-1 receptor.

Entrez Symbol:

PGF

Uniprot ID:

P49763-1

Data PDF:

CRH067

Source:

Human

Molecular Weight:

22.9/45.8 kDa Dimer, (204/408 aa)

Physical State:

Lyophilized

Formulation:

Sterile filtered aqueous solution containing 0.1% Trifluoroacetic Acid (TFA)

Purity:

> 95% by reducing and non-reducing SDS-PAGE.

Endotoxin Level:

≤1 EU/µg of protein by kinetic LAL analysis

Amino Acid Sequence:

MLPAVPPQQW ALSAGNGSSE VEVVPFQEVW GRSYCRALER LVDVVSEYPS EVEHMFSPSC VSLLRCTGCC GDENLHCVPV ETANVTMQLL KIRSGDRPSY VELTFSQHVR CECRHSPGRQ SPDMPGDFRA DAPSFLPPRR SLPMLFRMEW GCALTGSQSA VWPSSPVPEE IPRMHPGRNG KKQQRKPLRE KMKPERCGDA VPRR

Reconstitution:

Centrifuge vial prior to opening. Add sterile distilled water to a concentration of 0.1 mg/ml. Suspend the product by gently pipetting the solution down the sides of the vial. DO NOT VORTEX. Allow several minutes for complete reconstitution.

Storage/Stability:

Store as supplied at -20°C to -80°C for up to 1 year.