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PlGF, a member of the VEGF family, was originally discovered in the placenta, where it was proposed to regulate vascular development and trophoblast growth and differentiation. Unlike VEGF, which is required for angiogenesis and endothelial cell maintenance and binds both Flt-1/sFlt-1 and Flk-1, PlGF is redundant for vascular development and selectively binds Flt-1/sFlt-1. PlGF stimulates endothelial cell growth, migration, and survival and plays a central role in pathologic angiogenesis, including in cancer and tissue ischemia. PlGF concentrations increase throughout pregnancy, peaking during the third trimester, and falling thereafter, probably as a consequence of placental maturation. Despite interest in the utility of PlGF for clinical diagnostics, the role of PlGF in preeclampsia and in placental development is not well understood.
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