Recombinant Human RANK Receptor

Synonyms:

Tumor necrosis factor receptor superfamily member 11A, TNFRSF11A, CD265, Osteoclast differentiation factor, ODFR, Receptor activator of NF-KB

Species:

Human

Cat. No.:

CRR102B pdf (datasheet)

Quantity/Size:

100 μg

Price:

$520.00 BUY

Description:

RANKL and RANK are members of the TNF superfamily of ligands and receptors that play an important role in the regulation of specific immunity and bone turnover. RANK (receptor) was originally identified as a dendritic-cell-membrane protein, which by interacting with RANKL augments the ability of dendritic cells to stimulate naïve T cell proliferation and to promote the survival of RANK + T cells. RANK is also expressed in a variety of tissues including skeletal muscle, thymus, liver, colon, small intestine and adrenal gland. The RANK/RANKL interaction is important in the regulation of osteoclastogenesis and in dendritic-cell-mediated T cell immune responses. Impairments in RANK signaling have been implicated in the induction of expansile osteolysis and Paget disease of bone (PDB2).

Recombinant human sRANK receptor contains the TNFR homologous cysteine rich portion of the extracellular domain of RANK receptor.

Entrez Symbol:

TNFRSF11A

Uniprot ID:

Q9Y6Q6

Data PDF:

CRR102

Source:

E. coli

Molecular Weight:

19.3 kDa (175 aa)

Formulation:

Lyophilized from PBS.

Purity:

> 98% by SDS-PAGE & HPLC analyses

Biological Activity:

ED50 < 30-50 ng/ml, determined by its ability to inhibit sRANKL induced NFkappaB in RAW264.7 cells in the absence of any cross-linking, in the presence of 15ng/ml of recombinant sRANKL.

Endotoxin Level:

< 1 EU/μg

Amino Acid Sequence:

MQIAPPCTSE KHYEHLGRCC NKCEPGKYMS SKCTTTSDSV CLPCGP DEYL DSWNEEDKCL LHKVCDTGKA LVAVVAGNST TPRRCACTAG Y HWSQDCECC RRNTECAPGL GAQHPLQLNK DTVCKPCLAG YFSDAFS STD KCRPWTNCTF LGKRVEHHGT EKSDAVCSSS LPARK

Storage/Stability:

Stable for 1 year at -20°C to -80°C.