Recombinant Human sTNF-Receptor Type II

Synonyms:

Tumor necrosis factor receptor superfamily member 1B, TNFRSF1B, CD120b, TNF receptor 2, TNF-RII, Etanercept

Species:

Human

Cat. No.:

CRT105B pdf (datasheet)

Quantity/Size:

20 μg

Price:

$520.00 BUY

Description:

TNF-RII is a member of the TNFR family of transmembrane proteins, and is expressed in immune cells and certain endothelial cells. It is a high affinity receptor for TNF α but manifests a lower affinity to TNF-β. Signaling through this receptor regulates various biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, coagulation, and neurotransmission. Soluble TNFRII is capable of inhibiting TNF-α induced activities by acting as a decoy receptor. Recombinant human sTNFRII comprises the cysteine rich ligand binding portion of the extracellular domain of the TNFRII protein.

Entrez Symbol:

TNFRSF1B

Uniprot ID:

P20333

Data PDF:

CRT105B

Source:

E. coli

Molecular Weight:

18.9 kDa (174 aa)

Formulation:

Lyophilized from PBS

Purity:

> 98% by SDS-PAGE and HPLC analyses

Biological Activity:

ED50 typically 0.125 mg/ml, determined by its inhibitory effect of the TNF-α mediated cytotoxicity in mouse L929 cells, in the presence of 0.25 ng/ml of recombinant human TNF-α.

Endotoxin Level:

< 1 EU/µg

Amino Acid Sequence:

MAPEPGSTCR LREYYDQTAQ MCCSKCSPGQ HAKVFCTKTS DTVCDSCEDS TYTQLWNWVP ECLSCGSRCS SDQVETQACT REQNRICTCR PGWYCALSKQ EGCRLCAPLR KCRPGFGVAR PGTETSDVVC KPCAPGTFSN TTSSTDICRP HQICNVVAIP GNASMDAVCT STSP

Storage/Stability:

Stable for 1 year at -20°C to -80°C.