Recombinant Human TACI (ED)

Synonyms:

Tumor necrosis factor receptor superfamily member 13B, TNFRSF13B, Transmembrane activator and CAML interactor, CD267

Species:

Human

Cat. No.:

CRT700B pdf (datasheet)

Quantity/Size:

20 μg

Price:

$520.00 BUY

Description:

TACI, a member of the TNF Receptor superfamily, is expressed in the small intestine, spleen, thymus, peripheral blood leukocytes, activated T cells, and resting B cells. TACI binds to both APRIL and BAFF and can stimulate the activation of transcription factors; NF-kappaB, AP-1, and mediates calcineurin dependent activation of NF-AT (nuclearfactor of activated T cells). TACI also plays a key role in the stimulation of B and T cell function. Soluble TACI inhibits APRIL-stimulated proliferation of primary B-cells by blocking the binding of APRIL to the membrane anchored TACI receptor.

Entrez Symbol:

TNFRSF13B

Uniprot ID:

O14836

Data PDF:

CRT700B

Source:

E. coli

Molecular Weight:

17.8 kDa (160 aa)

Formulation:

Lyophilized from PBS

Purity:

> 98% by SDS-PAGE & HPLC analyses

Biological Activity:

Determined by its ability to block human BAFF induced T2B cell survival using a concentration range of 1.0-3.0 µg/ml.

Endotoxin Level:

< 1 EU/µg

Amino Acid Sequence:

MSGLGRSRRG GRSRVDQEER FPQGLWTGVA MRSCPEEQYW DPLLGTCMSC KTICNHQSQR TCAAFCRSLS CRKEQGKFYD HLLRDCISCA SICGQHPKQC AYFCENKLRS PVNLPPELRR QRSGEVENNS DNSGRYQGLE HRGSEASPAL PGLKLSADQV

Storage/Stability:

Stable for 1 year at -20°C to -80°C.