Recombinant Human TGF-beta 3 (Receptor Grade)

Synonyms:

Transforming growth factor beta-3

Species:

Human

Cat. No.:

BJU100 pdf (datasheet)

Quantity/Size:

100 μg

Price:

$460.00 BUY

Description:

TGF-β3 is one of three closely related mammalian members of the large TGF-β super family that share a characteristic cysteine-knot structure. TGF-β1, -β2 and -β3 are highly pleiotropic cytokines that regulate immune function, proliferation and epithelial mesenchymal transition. Each TGF-β isoform has some non-redundant functions. Human TGF-β3 cDNA encodes a 412 amino acid precursor that contains a 20 amino acid signal peptide and a 392 amino acid precursor. A furin-like convertase processes the precursor to generate an N terminal 220 amino acid latency associated peptide and a C terminal 112 amino acid mature TGF-β3. Mature human TGF-β3 shows 100%, 99% and 98% identity with mouse/dog/horse, rat and pig TGF-β3, respectively.

Entrez Symbol:

TGFB3

Data PDF:

BJU020

Source:

E. coli

Molecular Weight:

25.4 kDa

Formulation:

Lyophilized with mannitol

Purity:

> 95% by HPLC analysis

Biological Activity:

IC50 < 0.75 ng/ml, by inhibition of Mv1Lu cell proliferation

Endotoxin Level:

< 0.1 EU/µg

Amino Acid Sequence:

5 residues confirmed

Storage/Stability:

Store as supplied for up to 1 year at 2-8°C.