VEGFA

Vascular endothelial growth factor A, VEGF-A, Vascular permeability factor, VPF

Horse

CRE051D-AF pdf (datasheet)

100 μg

$560.00 BUY

Vascular Endothelial Growth Factor is a potent growth and angiogenic cytokine. It stimulates proliferation and survival of endothelial cells. VEGF-A is also a vasodilator and increases microvascular permeability and was originally referred to as vascular permeability factor. There are multiple isoforms of VEGF-A that result from alternative splicing of mRNA from a single, 8-exon VEGFA gene, with VEGF-165 being the most abundant. The VEGF-165 isoform is a secreted protein that acts on receptors VEGFR-1 and VEGFR-2 to modulate endothelial cell proliferation and angiogenesis.

Manufactured without Animal-derived products, in an Animal Free facility.

VEGFA

Vascular endothelial growth factor A

F6XLT6

CRE051-AF

E. coli

19.3/38.6 kDa (166/332 aa), dimer

Lyophilized

Sterile filtered 10 mM Sodium Phosphate, pH 7.5

> 95% by reducing and non-reducing SDS-PAGE

ED50 < 10 ng/ml, determined by dose-dependent cell proliferation assay using human umbilical vein endothelial cells (HUVEC).

> 1.0 × 10e5 units/mg

≤1 EU/µg of protein by kinetic LAL analysis

MAPMAEGEHK THEVVKFMDV YQRSYCRPIE TLVDIFQEYP DEIEYIFKPS CVPLMRCGGC CNDEGLECVP TAEFNITMQI MRIKPHQSQH IGEMSFLQHS KCECRPKKDK ARQENPCGPC SERRKHLFVQ DPQTCKCSCK NTDSRCKARQ LELNERTCRC DKPRR

Centrifuge vial prior to opening. Add sterile distilled water to a concentration of 0.1 mg/ml. Suspend the product by gently pipetting the solution down the sides of the vial. DO NOT VORTEX. Allow several minutes for complete reconstitution.

Store at -20°C to -80°C for up to 1 year.